Compr-DWO combines calming amino acids with an adaptogenic botanical and other essential ingredients to optimize the body’s Hypothalamus Pituitary Adrenal (HPA) axis. This axis controls catecholamine production and stress response – regulating key hormone and neurotransmitter production, distribution and metabolism. As a side benefit, COMPR-DWO helps the body manage inflammation however it may manifest.
All supplements are not created equally. Research has shown that certain ingredients commonly found in stress-oriented supplements can negatively affect the body’s biochemistry and cause unfavorable genetic expression. Compr DWO intentionally avoids such ingredients and yet is able to provide stress handling benefits in a gentle and effective way. Our formulation is clean and pure – free from gluten, dairy, and Genetically Modified Organisms (GMOs).
BENEFITS and systems supported:
• Positive Mood
• Muscle and nerve function
• GI Tract
• Blood sugar balance
• Hormonal balancing
• Hair & Skin
• Neurological health
Caution: Keep this product out of reach of children. Do not start taking any products without first discussing it with your primary care provider (PCP). Do not take if pregnant or lactating. Avoid is you are on any antidepressant or anti-anxiety medications. Discontinue use and consult your health care provider if you experience any adverse reactions including anxiety and insomnia.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
Compr-DWO is named after DWO – the Greek root for BALANCE. This formula was formulated especially to support the body’s healthy response to stress. Many stress-oriented supplements are available in the marketplace – our goal was to create one unlike any others. The formula is powerful and efficacious, but in a gentle way. It intentionally avoids many commonly used ingredients that may create negative side effects in some individuals. The formula works by supporting the Hypothalamus Pituitary Adrenal (HPA) axis – the body’s master of stress responses. The HPA axis also plays a role in regulating functions such as energy, digestion, temperature, mood, lymphatic flow, and immunity. A significant body of scientific literature has illuminated the negative consequences of stress – a weakened immune system, disrupted gastrointestinal function, impaired mood, suboptimal sleep, histamine response, etc. The body’s stress response is controlled by hormone and neurotransmitter metabolism – the exact target of COMPR-DWO. This supplement can also help athletes by optimizing stress handling – a key element of optimal athletic performance.
Phosphatidylserine is a phospholipid made in the body that plays a vital role in brain health. It helps maintain the structure of cell membranes and has been found in academic research to reduce stress and improve memory. Phosphatidylserine has also been noted to decrease the stress hormone response during exercise (1). It is also involved in regulating the pituitary-adrenal reactivity hormones, ACTH and cortisol, in response to emotional or mental stress (1). Overall, phosphatidylserine has been studied for its positive effects on age-related cognitive decline (3), mood (4), and athletic performance (5).
Manganese is an essential metal used for the development, growth, and normal functioning of our bodies. Manganese deficiency is associated with reduced fertility and can affect ovarian and testicular function; it is also associated with common PMS symptoms and impaired insulin production (6,7). Manganese has been shown to lower histamine levels – improving allergies and related conditions (8).
Glycine is an amino acid involved in a wide range of functions, including digestion, mood, and overall metabolic function (9, 10, 11).
Rhodiola rosea is a powerful extract of a plant adaptogen – a substance which modulates the stress response by either upregulating or downregulating endocrine function based on need. It also helps manage mental fatigue (12, 13, 14). It has the potential to protect athletes from exercise-induced fatigue and oxidative stress (15).
Taurine is an amino acid important for cell health. It helps control multiple biological processes in the body such as fighting oxidative stress, detoxification, neuromodulation, osmoregulation, conjugation of bile acids, and thermoregulation (16).
The benefits of each Compr-DWO ingredient are supported by extensive academic research. In addition, they work synergistically to address various facets of the HPA system, overall stress handling, and even tangential functions such as detoxification and gut health.
1) Hellhammer, J., E. Fries, C. Buss, V. Engert, A. Tuch, D. Rutenberg, and D. Hellhammer. “Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress.” Stress 7, no. 2 (2004): 119-126.
2) Hashioka, Sadayuki, Youn-Hee Han, Shunsuke Fujii, Takahiro Kato, Akira Monji, Hideo Utsumi, Makoto Sawada, Hiroshi Nakanishi, and Shigenobu Kanba. “Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation.” Free Radical Biology and Medicine 42, no. 7 (2007): 945-954.
3) Kato-Kataoka, Akito, Masashi Sakai, Rika Ebina, Chiaki Nonaka, Tsuguyoshi Asano, and Takashi Miyamori. “Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints.” Journal of clinical biochemistry and nutrition 47, no. 3 (2010): 246-255.
4) Hirayama, S., K. Terasawa, R. Rabeler, T. Hirayama, T. Inoue, Y. Tatsumi, M. Purpura, and R. Jäger. “The effect of phosphatidylserine administration on memory and symptoms of attention‐deficit hyperactivity disorder: a randomised, double‐blind, placebo‐controlled clinical trial.” Journal of human nutrition and dietetics 27, no. s2 (2014): 284-291.
5) Parker, Adam G., Josh Gordon, Aaron Thornton, Allyn Byars, John Lubker, Michelle Bartlett, Mike Byrd et al. “The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise.” Journal of the International Society of Sports Nutrition 8, no. 1 (2011): 16[HB11] .
6) Shamberger, Raymond J. “Calcium, magnesium, and other elements in the red blood cells and hair of normals and patients with premenstrual syndrome.” Biological trace element research 94, no. 2 (2003): 123-129.
7) Penland, James G., and Phyllis E. Johnson. “Dietary calcium and manganese effects on menstrual cycle symptoms.” American journal of obstetrics & gynecology 168, no. 5 (1993): 1417-1423.
8) Foreman, J. C., and J. L. Mongar. “The action of lanthanum and manganese on anaphylactic histamine secretion.” British journal of pharmacology 48, no. 3 (1973): 527-537.
9) Wang, Weiwei, Zhenlong Wu, Gang Lin, Shengdi Hu, Bin Wang, Zhaolai Dai, and Guoyao Wu. “Glycine Stimulates Protein Synthesis and Inhibits Oxidative Stress in Pig Small Intestinal Epithelial Cells, 2.” The Journal of nutrition 144, no. 10 (2014): 1540-1548.
10) McCarty, Mark F., and James J. DiNicolantonio. “The cardiometabolic benefits of glycine: Is glycine an ‘antidote’to dietary fructose?.” (2014): e000103.
11) Altamura, Carlo, Michael Maes, Jin Dai, and H. Y. Meltzer. “Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression.” European Neuropsychopharmacology 5 (1995): 71-75.
12) Palmeri, Agostino, Leonardo Mammana, Maria Rosaria Tropea, Walter Gulisano, and Daniela Puzzo. “Salidroside, a bioactive compound of rhodiola rosea, ameliorates memory and emotional behavior in adult mice.” Journal of Alzheimer’s Disease 52, no. 1 (2016): 65-75.
13) Xia, Nan, Jie Li, Hongwei Wang, Jian Wang, and Yangtian Wang. “Schisandra chinensis and Rhodiola rosea exert an anti-stress effect on the HPA axis and reduce hypothalamic c-Fos expression in rats subjected to repeated stress.” Experimental and therapeutic medicine 11, no. 1 (2016): 353-359.
14) Panossian, Alexander, Georg Wikman, Punit Kaur, and Alexzander Asea. “Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones.” Phytomedicine 16, no. 6-7 (2009): 617-622.
15) Ahmed, Maryam, Dru A. Henson, Matthew C. Sanderson, David C. Nieman, Jose M. Zubeldia, and R. Andrew Shanely. “Rhodiola rosea exerts antiviral activity in athletes following a competitive marathon race.” Frontiers in nutrition 2 (2015): 24.
16) Marcinkiewicz, Janusz, and Ewa Kontny. “Taurine and inflammatory diseases.” Amino acids 46, no. 1 (2014): 7-20.